Generic Fetzima Pills In Pakistan

Generic Fetzima is the active ingredient levomilnacipran hydrochloride extended?release capsules—a generic equivalent to the branded antidepressant Fetzima®. The U.S. Food and Drug Administration approved the generic formulation in March 2023, marking it as equivalent across strengths of 20?mg, 40?mg, 80?mg, and 120?mg Despite approval, commercial availability may remain limited due to ongoing market exclusivity and patent protections 

Indications & Mode of Action

Levomalnacipran is a serotonin?norepinephrine reuptake inhibitor (SNRI) indicated for the treatment of major depressive disorder in adults It selectively inhibits both serotonin and norepinephrine reuptake, providing a more balanced effect—especially with relatively greater norepinephrine activity compared to other SNRIs 

Dosage & Administration

Starting dose: Typically begins at 20?mg once daily, increasing to 40–120?mg once daily based on clinical response and tolerability Capsules must be swallowed whole, and can be taken with or without food .Discontinuation should be gradual to avoid withdrawal symptoms; long?term dosing adjustments depend on renal and patient-specific factors 

Side Effects & Safety Considerations

Common side effects may include:Nausea, vomiting, constipation, dry mouth, sweating, increased heart rate and blood pressure, dizziness, insomnia, and sexual dysfunction (e.g. erectile dysfunction, delayed ejaculation) 

Serious adverse effects to monitor:

Serotonin syndrome (especially if combined with MAO inhibitors or other serotonergic medications)Elevated blood pressure or heart rateHyponatremia, urinary hesitancy, angle?closure glaucoma, seizures, and activation of mania or suicidal ideation in young adults 

Precautions & Interactions

Not recommended in combination with MAO inhibitors, within 14 days of MAOI therapy, due to serious risk of serotonin syndrome Caution advised for patients with hypertension, cardiac conditions, renal impairment, glaucoma, bipolar disorder, or bleeding disorders. Monitor electrolytes in elderly populations due to risk of hyponatremia Avoid alcohol, and be aware of drug interactions with other serotonergic agents including triptans, opioids, linezolid, and herbal supplements like St. John’s wort 

Additional Insights & Limitations

Although generic levomilnacipran is FDA?approved, real-world availability remains sporadic, possibly due to regulatory exclusivity and market competition factor Some patient reports highlight significant benefits in motivation and cognitive function, while others report intolerable cardiac or neurocognitive side effects—with mixed user experiences on effectiveness