Addyi Flibanserin Tablets In Pakistan

Addyi is a hormonally neutral, prescription medication specifically approved to treat characterized by low sexual desire that causes marked personal distress and interpersonal difficulty, not due to medical, psychiatric, relationship, or medication-related causes

How It Works

Flibanserin exerts its effects centrally: it acts as a serotonin?1A receptor agonist and serotonin? receptor antagonist, with downstream increases in dopamine and norepinephrine and decreases in serotoninneurochemicals linked to sexual desire and inhibition Though the exact mechanism for improving desire isn’t fully understood, it is thought to rebalance brain activity associated with sexual interest.

Dosage & Administration

100?mg tablet taken with or without food.Taken at night to minimize the risk  drowsiness, dizziness)If no improvement is seen after 8 weeks, therapy should be discontinued Addyi is not for use for the treatment of  in women who have gone through menopause or in men or children. Addyi is not for use to enhance sexual performance.

Clinical Efficacy

Approval was based on three week randomized, double-blind, placebo-controlled trials involving premenopausal women with  flibanserin reported an average increase of  to (versus placebo’s  and small but statistically significant improvements in sexual desire scores .However, the overall benefit is modest, and some trials showed limited improvement in associated distress 

Safety & Side Effects

Most common adverse reactions  and more frequent than placebo dizziness, somnolence, nausea, fatigue, insomnia, dry mouth  highlights serious risks of hypotension and syncope, especially when combined with  or in women with  which are contraindications Updated labeling (since  allows limited alcohol use: wait at least before dosing, and if ≥?3 drinks have been consumed; no alcohol intake allowed after taking Addyi until the next day  depression risks are higher if taken during the day or alongside other depressants. Patients should avoid activities requiring alertness for at least 6 hours post-dose until their individual tolerance is known 

Contraindications & Interactions

Alcohol, hepatic impairment, and moderate or stronginhibitors are contraindications due to interactions causing elevated flibanserin levels and increased risk of adverse effects .Also avoid with  inhibitors, certain oral contraceptives, certain antifungals/antibiotics, HIV or Hepatitis C antivirals, etc. Use with caution if you’re taking digoxin or other narrow-index  substrates 

Usage Limitations

Not indicated for postmenopausal women, men, or children.Not intended for increasing sexual performance or for libido issues due to other causes like depression, relationship problems, or medications Let me know if you’d like a patient-friendly summary, comparisons with alternative therapies (like Vyleesi), or detailed profiling on interactions, cost, or access through certified programs.